Pathology, Microbiology & Immunology

Cardiovascular Development and Disease

Research on cardiovascular diseases are primarily pursued by faculty members in the Department of Cell Biology and Anatomy.  They are actively involved in research that focuses on molecular, structural and hormonal basis of cardiac and vascular development, injury, and repair following stress, and remodeling- associated changes.

The following is the list of names of faculty and their area of Cardiovascular Research: 

Gregory L. Brower, DVM, PhD  Role of cardiac mast cells, cytokines (i.e., TNF-alpha), adhesion proteins, integrins myocardial matrix metalloproteinases (MMPs),  angiotensin II  and gender in the mechanisms and regulatory events influencing cardiac remodeling during pathogenesis of heart failure.

Wayne E. Carver, PhD Extracellular matrix(fibroblast) behavior and gene expression in cardiovascular disease.

Taixing Cui, MD, PhD Molecular and cellular mechanism that links obesity, diabetes and vascular disease, with a specific focus on the role of ubiquitin-proteasome system (Keap1-mediated Nrf2 ubiquitination and deubiquitinating enzymes,UCH-L1- or CYLD) in the maintenance of vascular homeostasis.

Daping Fan, MD, PhD Role of macrophage Apolipoprotein E (ApoE), oxidized LDL (oxLDL), toll-like receptors (TLRs) and microRNA (miRNA155) in regression of  atherosclerotic plaques.

John Fuseler, PhD In vitro cardiac tissue regeneration

Edie Goldsmith, PhD Extracellular matrix, collagen, its receptor (DDR1 and DDR2) and gold nanoparticles in collagen remodeling and cardiac development.

Rich Goodwin, PhD Mechanisms of embryology, in vitro tissue regeneration, coronary vascular and cardiac regeneration.

Duncan Howe, PhD Cardiac Ultrasound Studies

Joseph S. Janicki, PhD Cardiac remodeling, role of tissue renin-angiotensin and angiotensin converting enzyme activity in cardiomyocyte hypertrophic response.

Sue Lessner, PhD Mechanical properties of mouse atherosclerotic lesions, and to develop mathematical models to describe their biomechanical behavior before and after drug treatment.

Mitzi Nagarkatti, PhD Immunotherapy for Cardiovascular disorders; vascular leak syndrome

Prakash Nagarkatti, PhD Role of immune cells in vasculitis

Jennifer Nyland, PhD Environmental Toxicants and Cardiovascular Disease

Chandrashekhar Patel, PhD Molecular regulation of vascular endothelial and smooth muscle cells.

Jay D. Potts, PhD Congenital cardiac malformations- Development of  atrioventricular  (AV) canal – AV valves and interventicular septum

Robert Price, PhD Molecular and cell biology instrumentation for in vitro, in vivo and whole body imaging studies of embryonic, fetal, neonatal and adult animals. Primary interests involve the roles of growth factors and mechanical forces on the development and function of myofibrils in cardiac myocytes.

Ann Ramsdell, PhD Etiology of congenital heart defects- emphasis on role of cardiac laterality genes in overall heart morphogenesis.

Ali Rizvi, MD Diabetes and Cardiovascular disease

Sarah Sweitzer, PhD Endothelin-1 and hypertension

Patricia Witherspoon, MD Community Health Care Advocacy and Cardiovascular Diseases