Pathology, Microbiology & Immunology

Inflammation

Inflammation is a process in which our body’s immune system mounts a reaction to get rid of primarily the infections.  This is followed by repair of damaged tissue.  Inflammation is carefully regulated such that after the infection is cleared or following healing of tissue damage it is restored to the naïve state.  However, often the process of severe acute and chronic inflammation can also cause significant tissue destruction.   Inflammation plays a key role in the pathogenesis of over 80 known autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and autoimmune thyroiditis.
In addition to the autoimmune diseases, it is becoming increasingly clear that inflammation plays a critical role in the pathogenesis of a wide range of clinical disorders including cardiovascular and neurodegenerative as well as certain types of cancer. 
USC SOM has major research strengths in Inflammation. It hosts the NIH Center for Inflammation, a $6 million Center that investigates the effect of Complementary and Alternative Medicine, specifically the effect of botanicals on inflammatory diseases. 
The following are the research interests of faculty in inflammation as it relates to various diseases: 

Autoimmune Hepatitis

Colitis and Colon Cancer

Graft vs Host Disease, Transplantation

Brain Disorders, Cancer and Diseases:

 
Diabetes:

Cardiovascular Disease:

Exercise and Health: