Pathology, Microbiology & Immunology

NEUROSCIENCE

The following is the list of faculty with research interests in Neuroscience at the University of South Carolina School of Medicine. Neuroscience-based research targets neurological and neuropsychiatric disorders including alcohol and drugs of abuse, chronic pain, cognitive deficits, aging and neurodegenerative disorders, neurological complications of diabetes, epilepsy and seizure disorders, as well as stress, anxiety and depression. Many investigators use virus-mediated gene transfer approaches targeting the brain, spinal cord or even myocytes to alter gene expression or model disease states.   Neuroscience research at the School of Medicine also includes several translational components including drug discovery and clinical/pre-clinical trials.


Anxiety, Depression, & Stress Disorders

Epilepsy & Seizure Disorders

  • GABAA Receptor modulators in seizure disorders:J Fisher
  • Glutamate receptors in epileptogenesis:D Mott
  • Functional properties of GABAA and glutamate receptors: J Fisher; D Mott
  • Anxiety-related changes in seizure disorders: D Mott, MA Wilson
  • Novel GABAA receptor modulators: J Fisher, D Mott

Complications of Diabetes, Obesity and Metabolic Disorders

Disorders of Cognition and Aging

  • Basal forebrain cholinergic system in aging-related deficits: JR Fadel
  • Cyclic nucleotide signaling in neurocognitive deficits: MP Kelly
  • Novel therapeutic targets for schizophrenia and bipolar disease: MP Kelly
  • Cognitive deficits in depression and diabetes: LP Reagan, CA Grillo
  • Prefrontal cortex and cognition: JR Fadel
    Protein modifications and mitochondrial stress in Parkinson’s disease: N Frizzell
    Amygdalar neuroanatomy and cognition: AJ McDonald

Stress, Cardiovascular Control & Nociception

  • Development of pain mechanisms: SM Sweitzer
  • Nociception and cardiovascular control: LB Wilson
  • Cell-based screening assays for drug discovery: K Walsh
  • Cardiovascular changes in depression: S Wood
  • Insular cortex, sensory integration and perception: JR Augustine

Alcohol and Drugs of Abuse

Neural Disease and Multiple Sclerosis

Stroke

  • Acute stroke treatment, stroke and TIA pathophysiology, stroke prevention and epidemiology - Souvik Sen, MD, MPH

Neuropsychiatry

  • Neurobiology and novel pharmacological interventions in autism,  mood disorders, anxiety disorders, schizophrenia and co-morbid substance use disorder - Meera Narasimhan, MD